Postdoc Position to Study Development and Function of Human Neurons Transplanted in the Mouse Brain

Postdoc Position to Study Development and Function of Human Neurons Transplanted in the Mouse Brain

VIB

Leuven, Belgium

Job description

This highly multidisciplinary project will combine cutting-edge approaches including human pluripotent stem cell technology, mouse brain transplantation, electrophysiology, two-photon cellular imaging in vivo, optogenetics, and viral tracing.

The project will be undertaken in active collaboration with the Vision-to-Action Laboratory (Vincent Bonin, PI) at Neuro-Electronics Research Flanders in Leuven, Belgium, (NERF).

Using a combination of patch-clamp recordings and in vivo functional imaging, the candidate will investigate the function and plasticity of human cortical pyramidal neurons xenotransplanted in the mouse brain. This technology was pioneered in the Vanderhaeghen lab (Gaspard Nature 2008; Espuny-Camacho Neuron 2013; Neuron 2017; Cell Reports 2018) and constitutes a unique in vivo model to gain insights on human-specific features of cortical neurons, from their developmental patterns to functional integration into neural circuits. It is also used to model specific human brain diseases and to explore the rational design of brain repair targeting the neocortex.

Profile

  • We are seeking highly motivated individuals with a strong expertise and interest in neuronal circuit function and/or assembly.
  • PhD in neuroscience, biology or related field.
  • Strong experience in electrophysiology or in vivo multiphoton imaging are required. We seek a highly motivated individual with strong quantitative and technical skills and a collaborative spirit.
  • Creative, enthusiastic, critically thinking, enjoy teamwork and excellent oral and written communication skills in English.
  • Molecular biology, systems, cognitive or behavioral neuroscience experience are a plus but not a requirement.

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© EuroJobsites 2019

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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