Postdoctoral Position to Conduct Genetic and Statistical Analyses in the Breast Cancer Genetic Predisposition
Postdoctoral Position to Conduct Genetic and Statistical Analyses in the Breast Cancer Genetic Predisposition
IFOM The FIRC Institute of Molecular Oncology Foundation
Milan, Italy
About the position
Open position for a post-doc to work in the Cancer Genetic Predisposition group lead by Paolo Peterlongo within the Genome Diagnostics Program at IFOM in Milan. We have a long-standing research activity in studying the genetic predisposition to breast and ovarian cancer. Several projects have been conducted locally in collaboration with colleagues from INT and IEO in Milan and many other Centers in Italy, and internationally especially with members of large consortia such BCAC – Breast Cancer Association Consortium; CIMBA – Consortium of Investigators of BRCA1/2 Modifiers; ENIGMA – Evidence-based Network for the Interpretation of Germline Mutant Alleles; CONFLUENCE. In particular, covered by funds from an AIRC IG (2019-2024) we are now studying the risk effect of the different sequence variants in the novel breast cancer predisposition gene FANCM. To this aim, we are conducting i) functional experiments and ii) performing genetic analyses and meta-analyses in large international databases and pedigrees.
Required skills
Applicants need to have a PhD degree (or equivalent) in cancer genetics, statistics or genetic epidemiology.
The ideal candidate has:
- hands-on experience on management and curation of large genetic/clinical databases;
- He/she should be able to perform:
- genetic association studies by applying logistic regression or linear regression models;
- analysis of survival data by Cox regression and Kaplan-Meier curves;
- meta-analyses of case/control studies;
- Ability to use statistical tools and programming languages such as STATA or R;
- annotation and clinical interpretation of pathogenicity of genetic variants detected by NGS;
- knowledge of online databases such as ClinVar, BRCA Exchange, and gnomAD are required.
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