In human fungal pathogens, extracellular vesicles have been shown to play a role in cell intercommunication and host pathogen interactions. Yet, the physical bases of the exchanged messages and their mechanism of action remain mostly unknown. By analogy with other systems, one can anticipate that some RNAs could play essential roles. This project will study the fungal EV transcriptome structure and of its variation in response to environmental cues. It is also aimed to set up in vitro communication assays to decipher the mechanisms by which the EV message is sent and received in fungi. Finally, it seeks to understand the impact of cell-to-cell intercommunication in host-pathogen interactions.
The Janbon lab is part of the Mycology Department at the Institut Pasteur. Guilhem Janbon is also one the leader of the Pasteur International unit “Fungal extracellular vesicles” together with Robin May (University of Birmingham, UK) and Marcio Rodrigues (Fiocruz, Brazil). Part of the work will be carried out in collaboration with the May lab and the Drummond lab (University of Birmingham, UK). The Institut Pasteur is an equal opportunity employer and offers a vibrant scientific environment with a particular focus on microbiology and the study of infectious diseases.
We seek a highly motivated individual with a Ph. D degree in microbiology, mycology and/or related field. The candidate should have significant research experience, a strong publication record, as well as excellent verbal and written English communication skills. Speaking French is not mandatory. Knowledge of computer programming (python, R) is advantageous, but not required. Recent PhD graduates with experience in fungal genetics, transcriptomic and biochemistry are preferred. Experience in the study of host pathogen interactions would be a plus. The candidate will be encouraged to apply for internal and external funding opportunities. The position is for 3 years, and the candidate will be expected to start early 2024.