A Junior Postdoctoral position is opening up at the Center for Synaptic Neuroscience and Technology (NSYN) of the Italian Institute of Technology (IIT), at IRCCS San Martino Hospital (Genoa, Italy) for the study of the functional and structural plasticity underlying memory and disease (see Grasselli et al., Cell Rep 2016 14:2546–2553; Paonessa et al., Proc. Natl. Acad. Sci. USA 2016 113:91-100; Grasselli et al., 2013 Br J Pharmacol 2013 168:502-17; Grasselli et al., PLoS ONE 2011 6: e20791.
The project focuses on the cerebellum as a model brain area and will take advantage of conditional knockout murine strains, in vivo delivery of viral vectors for protein/shRNA expression, confocal microscopy, patch-clamp electrophysiology, optogenetics and time-lapse imaging. It aims at clarifying how modulations of intrinsic excitability affect axonal morphology and how axonal structural plasticity affects circuit function in memory coding and in the pathogenesis of several diseases, including Multiple Sclerosis and Epilepsy.
The candidate should have a relevant PhD, be highly motivated, collaborative, and able to work independently. He/she will have excellent written and verbal communication skills in English. Previous experience in patch-clamp electrophysiology in brain slices and data analysis, stereotactic surgery, immunohistochemistry, confocal microscopy and image analysis will be appreciated.