Postdoctoral Researcher in Structural Biology
Postdoctoral Researcher in Structural Biology
University of Helsinki - Institute of Biotechnology
Helsinki, Finland
The HiLIFE - Institute of Biotechnology at the University of Helsinki, renowned for its international research excellence, is excited to announce an opening for a postdoctoral researcher to join the group of Dr. Tommi Kajander.
Project Description
The research in this project is focused on structural biology and biophysics of protein interactions in neuronal synapse function and in regulation of synapse loss in Alzheimer’s disease (AD) by the complement system (see e.g Chernyaeva et al. EMBO Reports (2023)). We have long standing interest in complement research (e.g. Kajander et al. PNAS (2011); Bhattacharjee et al. J Biol Chem (2013)), and synaptic adhesion (e.g. Karki et al. Sci Reports (2020), Kim et al. PNAS (2022)). Other projects in the group focus currently e.g. on endoplasmic reticulum stress response regulation, and overall on the HiLIFE protein crystallization core facility operation and related projects.
The successful candidate will work on protein production and molecular interaction studies of complement proteins protective of neuronal synapses in AD, in collaboration with Dr. Karita Haapasalo’s group at the medical faculty. Specifically, protein-protein interactions of complement proteins and ApoE and synaptic proteins will be studied biophysically, biochemically, and by structural biology methods to visualize at the atomic level the protein interactions involved in the complement function at the synapse in disease states.
About you
- You are ambitious, goal-oriented, collegial and motivated to tackle challenging new projects;
- Have PhD degree in (or in final stages to submit) in protein biochemistry/molecular biology/molecular biophysics;
- Prior experience in protein biochemistry and expression and purification (FPLC) and molecular biology is essential;
- Expertise in some degree of cell culture work (e.g. insect cell expression) and molecular biophysics is desired;
- High interest in learning/knowledge of structural biology techniques (X-ray crystallography and CryoEM);
- Commitment to scientific excellence as demonstrated by a publication record;
- Excellent command of English (working language at the institute);
- Strong communication, interpersonal, organizational and time management skills.
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