Postdoctoral Fellowship in Single-cell Spatial Multi-omics

Postdoctoral Fellowship in Single-cell Spatial Multi-omics

University of Helsinki

Helsinki, Finland

Our research

A postdoctoral position based on the Research Council of Finland is provided in Rafa Najumudeen’s lab, located at Institute of Biotechnology, University of Helsinki, Finland. The lab is part of Institute of Molecular Medicine (FIMM) and Helsinki Institute for Life Sciences.

We have previously discovered how cellular metabolism changes during colon cancer initiation and progression (Najumudeen, Nature Genetics, 2021) and combining multi-omics approaches can identify new targets for colon cancer (Vande Voorde, Nature Metabolism, 2023). The oncogenic status of cancer cells alters the metabolic program of cancer cells and cancer metastasis (Najumudeen, Nature Comms, 2024). One of our aims is to integrate single-cell and spatial information from spatial metabolomics and transcriptomic data to understand the metabolism of intestinal stem cells and cancer and associate the findings to clinical data using machine learning.

The postdoctoral fellow will perform studies on the metabolism of healthy intestinal cells and tumour initiating cells using state-of-the-art mouse models, in vivo gene editing tools, organoid cultures combined with single cell transcriptomics and single cell spatial multi-omics methods (metabolomics, transcriptomics and proteomics). The candidates are expected to develop their own project with new research questions and using tools that will later support launch towards an ambitious independent career.

Your mission

We are seeking an ambitious fellow with a PhD and strong background in one or more of the following fields:

  • Primary stem cell systems;
  • Metabolism;
  • Spatial Omics methods;
  • Transcriptomics/epigenetics;
  • Experience with preclinical cancer models, mouse work are considered a benefit.

Candidates are also encouraged to start new projects and research directions. Applicants must be able to perform as part of a team as well as independently, have good social skills and communication skills in English. Basic knowledge and interest in cancer biology or metabolism are expected. Candidates are expected to co-mentor doctoral and master’s students.

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