In our group, we study the evolution of microorganisms and their main cellular processes by using a combination of in silico and wet-lab approaches. We have recently addressed one of the most important transitions in the history of Bacteria: that between cell envelopes with one membrane (monoderm) or two membranes (diderm). We showed that the ancestor of all Bacteria was already a complex diderm and that monoderms arose multiple times independently through loss of the outer membrane. To understand this major transition, we have developed a new experimental model, the diderm Firmicute Veillonella parvula (Negativicutes), an important anaerobic member of the human microbiome. A large range of protocols and genetic tools are now available in our lab to manipulate this bacterium and characterize its envelope. We have recently managed to obtain a V. parvula mutant where the outer membrane is highly destabilized, opening multiple possibilities to study the diderm-to-monoderm transition in the lab.
The hired postdoc will have three main aims:
The candidate should hold a PhD and have a strong background in bacterial genetics. Previous experience in bacterial envelopes, high-resolution microscopy, and/or manipulation of anaerobes is welcome although not necessary. A strong interest in microbial evolution and vivid scientific curiosity are essential qualities for this position. The postdoctoral fellow will enjoy a highly interdisciplinary and collaborative environment within a group of complementary expertise and subjects (experimental/bioinformatics; bacteria/archaea).
The position is immediately available. Ideal starting date could be January 2024. Benefits include comprehensive healthcare coverage for the fellow and their family, and 8 weeks paid annual leave. The Institut Pasteur is in the center of Paris, it has multiple state of-the-art facilities and constitutes a vibrant research community with 13 Departments across the Biology/Physics/Biomedical fields.