The group of Fabrizio d’Adda di Fagagna studies the role of DNA damage response (DDR) activation in biologically-relevant settings such as aging and cancer with a special emphasis on cellular senescence (d’Adda di Fagagna Nature 2003, Di Micco Nature 2006, Fumagalli Nature Cell Biology 2012).
Our previous basic findings (Francia Nature 2012, Michelini Nature Cell Biology 2017, Pessina Nature Cell Biology 2019), and our most recent results in vivo (Rossiello Nature Communications 2017, Aguado Nature Communications 2019), demonstrated the efficacy of novel antisense oligonucleotide (ASO) tools to selectively inhibit DDR activation at dysfunctional telomeres, reducing senescence burden and improving healthspan and lifespan.
We have an immediately available opening for an experienced and motivated researcher at the postdoctoral level to study the impact of telomeric DDR inhibition with ASO in mouse models of aging and aging-related disorders.
The successful applicant will hold a PhD and a demonstrated experience in mouse model. We seek skills in:
We seek a candidate with a background in aging and/or telomere dysfunction mouse models. Also candidates with experience with the in vivo use of ASO will be considered favorably. Experience in histopathological evaluations or bioinformatics skills is a plus.
Essential is a proven track record of productivity in international peer-reviewed journals. The candidate will be career-oriented, energetic, and capable to take full advantage of our interactive research environment. An attitude or demonstrated ability to translate basic findings into viable options for patients will be highly appreciated. For this reason, candidates transitioning from industry will be considered.