The Mass Spectrometry for Biology Lab headed by Julia Chamot-Rooke is a mixed Institut Pasteur/CNRS Unit. The main research axes of the Unit are: top-down proteomics and structural proteomics (in particular cross-linking mass spectrometry) with major applications in the field of infectious diseases. It is equipped with five Orbitrap mass spectrometers, including an Orbitrap Lumos with UVPD and ETD and an Orbitrap HF.
PhD (or post‐doc) in biological mass spectrometry or proteomics. Knowledge in sample preparation, mass spectrometry and in the bioinformatic tools used in proteomics is required. A first practical experience in top-down proteomics and/or Orbitrap MS would be a plus. Good communication, interpersonal skills and experience in presenting concepts and data in oral and written formats (English is necessary).
The objective of the project is to develop new top-down proteomics approaches for the analysis of challenging proteins such as intact antibodies and highly modified proteins important in human health. The developments will be undertaken in the framework of a European project named Topspec and another project funded by the French Research Agency.