Scientist Protein Biochemistry

TUM - Technical University Munich, Faculty of Chemistry

Scientist Protein Biochemistry

TUM - Technical University Munich, Faculty of Chemistry

Garching, Germany

JOB DESCRIPTION

We aim at developing next generation precision medicines for unmet medical needs. Our focus is the engineering of innovative immunomodulatory biologics. Within this endeavor, we have created alphaSEPT. AlphaSEPT is a novel signaling molecule within the human immune system. It is a potential first-in-class pharmaceutical to treat sepsis, an infectious disease with very high mortality rates and no causative treatment options available. Currently, we are looking for a highly motivated protein biochemist to strengthen our newly established team.

The ideal candidate will drive early pre-clinical development of alphaSEPT. He/She will work on the production, biophysical characterization and development of alphaSEPT towards a biopharmaceutical ready for the clinics. The candidate will work in the in-house lab as well as with several academic cooperation partners at other institutions and contract research organizations (CROs).

RESPONSIBILITIES

  • Development of a lead candidate via protein engineering;
  • Protein expression from mammalian and bacterial cell cultures;
  • Protein purification via advanced techniques;
  • Biophysical characterization of proteins;
  • Drug substance formulation development;
  • Development lead of a master cell bank;
  • Data analysis and presentations;
  • Establishing of standard operating procedures (SOPs);
  • Lead of a small team.

QUALIFICATIONS

  • PhD in protein biochemistry or similar fields;
  • Substantial expertise in mammalian cell culture;
  • Substantial expertise in protein engineering, protein expression, protein purification and biophysical characterization;
  • Experience in (pre-)clinical development of biopharmaceuticals (e.g. formulation development) and molecular immunology is a plus;
  • Know-how in GLP and GMP requirements is a plus.

THE ENVIRONMENT AND THE POSITION

The position is associated with the laboratory of Cellular Protein Biochemistry (www.cell.ch.tum.de) at the Technical University of Munich (TUM), a leading research university in Europe. The salary is in accordance to the Public Sector Collective Agreement on Länder (TV-L E13/100%). The position is limited to two years. The earliest starting date is October 1st 2020. Only applications received until August 31st 2020 will be considered.

We are looking forward to your application including a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application as a single pdf- document by email to: matthias.feige@tum.de.

TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.

Don't forget to mention EuroScienceJobs when applying.

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© EuroJobsites 2020

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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