Post-doc Position – In Vitro Electrophysiology for Biohybrid Brain Regeneration

Post-doc Position – In Vitro Electrophysiology for Biohybrid Brain Regeneration

IIT - Istituto Italiano di Tecnologia

Genoa, Italy

The Enhanced Regenerative Medicine Research Line invites applications for 1 post-doc position to conduct brain slice and brain organoid electrophysiology experiments within the context of a cross-disciplinary European project aimed at repairing the epileptic brain by means of functional intelligent biohybrids.

The project aims at demonstrating the proof-of-concept that a biohybrid interplay can be successfully established to achieve controlled brain regeneration. The biohybrid construct will merge together bioengineered hippocampal tissue (graft), mammalian brain tissue (host), a neuromorphic chip (artificial counterpart) and artificial intelligence (coordinator).

This is a high-risk/high-gain visionary project funded by the EU FET Proactive scheme (Grant Agreement n. 824164 - Acronym: HERMES - Title: "Hybrid Enhanced Regenerative Medicine Systems"). The research consortium gathers together experts in tissue/organoid bioengineering, biomaterials, in vitro and in vivo electrophysiology, neuromorphic engineering, machine learning, artificial intelligence, communication, philosophy, ethics and policy. If selected, you will work in a highly stimulating environment promoting close collaboration with all these experts.

Your work will mainly consist of brain slice and brain organoid MEA/silicon probes electrophysiology, using open-loop and closed-loop architectures based on Simulink environment and custom boards designed and fabricated by the project partners.

Within the team, you will contribute to:

  • designing and conducting electrophysiology experiments;
  • collecting, analyzing and interpreting experimental data;
  • archiving experimental data according to the Data Management Plan;
  • preparing the project periodic reports;
  • tutoring PhD students under the PI supervision.

Fundamental experimental skills:

  • strong track record of hands-on experience with brain slice electrophysiology (MEA and/or field potential recording) applied to in vitro models of temporal lobe epilepsy such as 4-aminopyridine or zero magnesium;
  • knowledge of network interactions in temporal lobe epilepsy, particularly the hippocampus-cortex interplay;
  • experience with electrical stimulation protocols, such as electrical modulation of epileptiform activity, LTP, LTD, paired-pulse facilitation and depression.

Fundamental personal skills:

  • capable of working in a fast-paced environment with strict deadlines;
  • team-oriented collaborative attitude;
  • highly motivated, curious and goal-oriented;
  • creative thinking;
  • proactive mindset and independent thinking;
  • problem-solving;
  • excellent written and spoken English.

Plus:

  • FELASA or equivalent personal certification;
  • hands-on experience with the pilocarpine model of temporal lobe epilepsy;
  • knowledge of MATLAB programming language and Simulink environment;
  • signal processing;
  • work experience within multi/cross-disciplinary teams;
  • international experience;
  • work experience with commercial/industrial companies.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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