Postdoc - Mass Spectrometry and Molecular Biology of Epigenetic DNA/RNA Modifications

Postdoc - Mass Spectrometry and Molecular Biology of Epigenetic DNA/RNA Modifications

IMB - Institute of Molecular Biology

Mainz, Germany

The ERC-funded laboratory of Christof Niehrs studies regulatory DNA and RNA modifications, which play important roles in development & disease. We utilize highly sensitive mass spectrometry (Triple Quadrupole Mass Spec) and stable isotope metabolic labelling to profile epigenetic and epitranscriptomic changes, including 5mC, 5hmC, 5fC, 5caC, m6A, and others. The successful candidate will study nucleic acid modifying enzymes to unravel how chemical modifications in DNA, RNA and R-loops regulate pluripotency and differentiation of mammalian embryonic stem cells and embryos. You will use mass spectrometry, genome-edited CRISPR/Cas9 stem cell mutants, as well as various NGS protocols to carry out a multi- dimensional analysis to address: Which modifications can be identified and how do they change with different cellular states? Where in the genome and in which RNAs do the modifications occur? What are molecular determinants involved in targeting of modifications to specific sites? The project will involve strong interaction with computational biologists.

You have

  • PhD & publications in a relevant field;
  • Experience in RNA/DNA biochemistry;
  • Excellent communication skills and good team spirit;
  • Ability to solve problems independently;
  • Fluent in English (spoken and written).

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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