Our lab has contributed to the understanding of the molecular and physical mechanisms that drive tumor cell migration. More specifically, we have recently uncovered a process whereby solid and packed tumors, particularly in the context of breast ductal carcinoma, overcome such a suppressive crowded environment to acquire liquid-like material properties that lead to the reawakening of a flocking mode of streaming motion that facilitates the collective invasion into the collagen-rich stromal microenvironment. This work has been conducted in close collaboration with physicists at the University of Milan with expertise in soft matter and their rheological properties.
We are seeking an applicant to work with a well-established team to investigate the mechanisms and molecular basis of the transition from a solid-sessile to a collective locomotory state during the progression of breast ductal carcinoma. The position, funded by AIRC, is for three years, renewable.
Multiple and interdisciplinary approaches including high-end light and real-time microscopy, human organoids, and 3D cultures, molecular and cellular biology, CRISPR/ RNAi will be applied. Knowledge and experience in bio-mechanics and more general in biophysics and quantitative biology will be a plus.
Applicants must have a recent Ph.D. in the field of cell biology, molecular biology, biotechnology, physics or biophysics. The successful candidate should have demonstrated productivity in related fields and have the talent and dedication to take advantage of the vast resources available at IFOM. The ability to work in a team is mandatory.