To work within the Group of Professor Julian Gough at the Laboratory of Molecular Biology (LMB), within a programme aimed at cell fate and evolution. Specifically to undertake research to computationally investigate Cell Reprogramming.
We have created a system ‘Mogrify’ based on cellular networks to predict transcription factors for reprogramming one human cell type into another (Rackham et al. Nature Genetics 2016). This has been experimentally validated by proving several novel conversions, and we are validating many more. There is a great deal more research to do on cell reprogramming, e.g. with regard to: epigenetic factors, down-regulation, different sequencing technologies, sources of network interactions and synthetic cell types. The work is anticipated to be predominantly molecular biology bioinformatics research.
You will report to Professor Julian Gough and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.