Postdoctoral Researcher in Virus-host Interactions

Postdoctoral Researcher in Virus-host Interactions

University of Helsinki - Faculty of Agriculture and Forestry

Helsinki, Finland

The research group of Dr. Tero Ahola, studying RNA virus replication and antivirals, in the Department of Microbiology, University of Helsinki, is recruiting a postdoctoral researcher to study virus - host cell interactions in alphaviruses.

Viruses with RNA genomes cause most of the emerging and re-emerging infectious disease epidemics. Alphaviruses are mosquito-borne viruses causing febrile disease, found both in tropical and temperate regions. The project aims to establish a comprehensive view of host interaction during alphavirus replication by identifying host proteins that assist in virus replication. We aim to understand the specific actions that each host factor performs during virus replication. The proteins could assist e.g. in the modification of host cell membranes, as viruses rearrange the membranes to create protective replication vesicles. The host proteins important for virus replication are attractive new targets for antiviral drugs. The starting point of the project is a large proteomics dataset, so the project can be tailored together with the successful applicant based on their interest and prior experience. The work could include detailed virological, cell biological, or biochemical/structural characterization of the selected protein(s). We are supported by top-level local core facilities in proteomics, as well as light and electron microscopy and sequencing. The project entails collaboration with other teams and universities.

Qualifications

  • You are ambitious, goal-oriented, collegial and motivated to tackle challenging new projects;
  • Have a PhD degree in (or in final stages to submit) in molecular or cell biology, biochemistry or virology;
  • Commitment to scientific excellence as demonstrated by a publication record;
  • Prior laboratory experience in working with mammalian cell cultures is essential;
  • High interest in learning and adapting new skillsets, and readiness to work with diverse teams;
  • Excellent command of English (working language, oral presentations, writing skills);
  • Strong communication, interpersonal, organizational and time management skills;
  • Readiness to apply for national and international funding schemes.

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