APPLICATION CLOSING DATE: January 15th, 2024
Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.
The Human Technopole Foundation is looking for two Postdoctoral fellows to work in the Structural Biology Research Centre in the laboratory of Prof. Alessandro Vannini.
The Vannini Group combines cryo-electron microscopy (both SPA and cryo-ET), mass spectrometry, single molecule analisys and various biophysical techniques to elucidate the role of multi-subunit macromolecular machineries involved in genome function and organization. In particular, we are interested in understanding at the molecular level how the SMC complexes (Condenisn I and II) and general transcription factors (TFIIIC), together with specific auxiliary factors and chromatin remodellers, control the architecture of the human genome throughout the cell cycle.
The HT Centre of Structural Biology has top-notch managed facilities for Cryo-EM (Titan Krios, 1 Glacios, 1 Aquilos2, 1 Spectra, 1 Talos 120), cryo-CLEM, Light imaging, XL- and native mass -pectrometry and support units for Biophysics (mass photometry, SEC-MALLS, ITC, x-ray crystallography etc.), Biomass production (E,coli, yeast, insect cells, suspension mammalian cells with fermenters up to 150 litres) and a dedicated managed platform for single molecule experiments on optical tweezers (Lumicks C-trap and M-trap).
We are looking for highly motivated and creative individuals with a strong interest in structural and functional characterization of large multi-subunit complexes, using integrative approaches. Previous expertise in structural biology or, in alternative, RNA biochemistry is essential. We encourage international candidates to apply and will support applications to external Postdoctoral fellowship schemes (EMBO, Marie Curie, HPSF, etc.), for which we have an outstanding record of success.
On the closing date for online applications, the candidate must fulfil all the following conditions:
HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.
Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.
We believe that highly diverse teams yield the best and most innovative results.
We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.
Special consideration will be given to candidates who are part of the protected categories list, according to L. 68/99.
Number of positions offered: 2
Contract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years - employee level.