Postdoc in RNA Therapeutics

Postdoc in RNA Therapeutics

Aalborg University - Department of Clinical Medicine

Copenhagen, Denmark

Job description

The Center for RNA Medicine is looking for a highly motivated and exceptional candidate with a keen interest in molecular biology, particularly in relation to Parkinson's Disease(PD), microRNA biology, and RNA-based therapeutics. The primary goal of the PARMED project is to advance our innovative RNA-based therapies for PD to clinical trials. The successful candidate will be responsible for conducting research during the early development stages of our lead compounds. This research will encompass a range of activities, starting from Proof-of-Concept studies in mouse models of PD, and extending to biodistribution/PK studies in non-human primates(NHP). The candidate will be expected to explore the therapeutic potential of antisense oligonucleotides(ASOs) in various animal models of PD. This exploration will involve utilizing multiple techniques, such as RNA-seq, qPCR, hybridization ELISA, and imaging. Furthermore, the candidate will be in charge of investigating changes in miRNA levels in brain and plasma, assess their effects on downstream targets, and evaluate how these changes impact PD-related phenotypes. This research will be conducted in close collaboration with bioinformaticians, as well as molecular and cell biologists from the Center for RNA Medicine, Neumirna Therapeutics, and partners within the PARMED Consortium.

Furthermore, the successful candidate for the postdoc position should possess the following qualifications:

• A PhD degree in Biochemistry, Molecular Biology, RNA Biology or a similar area;
• Strong background in cell and molecular biology and in miRNA research;
• Skilled within mammalian cell culture, RNA technologies, and animal studies;
• Prior experience working with omics and RNA-seq data analysis is an advantage;
• Solid publication track record in RNA journals as first or lead author;
• Strong communication skills and ability to work effectively in a highly collaborative research environment;
• Excellent English skills.

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