A postdoctoral position is available at the Biology of Intracellular Bacteria Unit (BBI) at Institut Pasteur, led by Prof. Carmen Buchrieser. The BBI Unit is an international team that focuses on understanding the genetic, cellular, and molecular basis of infection by intracellular bacteria. We have recently discovered how Legionella pneumophila, the intracellular bacterium that causes Legionaries’ disease, impacts mitochondrial functions in infected human macrophages. The current project “Using Comparative Patho-Metabolomics To Decipher How Intracellular Bacteria Subvert Macrophage Immunometabolism“ aims to identify which specific metabolic pathways are subverted by intracellular bacteria during infection of human macrophages and its impact on their immunometabolism. By using Salmonella enterica ser. Typhimurium and Legionella pneumophila as models, the selected candidate will combine state-of-the-art metabolomics, high-dimensional immunophenotyping and robust computational analyses to study infection of human primary macrophages.
Applicants must hold a PhD in a relevant field. He/she should be experienced in at least one of the following fields and have the enthusiasm for learning the others during his/her postdoctoral training: cell biology, cellular microbiology, mass spectrometry, and/or metabolomics. The candidate should be a good team player, be independent and be collaborative as he/she will work in close interaction with the Metabolomics Core Facility of Institut Pasteur