Postdoctoral Researcher Medicinal Chemistry and Proline-specific Proteases
University of Antwerp
You will be working in the research group Medicinal Chemistry (UAMC) on lead optimization of inhibitors and activity-based probes for proline-specific proteases. These enzymes are drug targets in, among others, oncology;
Background research topic: UAMC has longstanding expertise with developing small molecule ligands (inhibitors, activity-based probes) for proline-specific proteases that are involved in human disease. In this project you will develop ligands for proline selective proteases that have key roles in tumor biology. Developed ligands will be evaluated for target affinity and selectivity in collaboration with the Medical Biochemistry group at University of Antwerp. Promising molecules will be evaluated in in vitro and, eventually, in vivo models of cancer;
Research topic for this postdoc position: Synthetic lead optimization of inhibitors and activity-based Probes for proline-specific proteases;
Next to experimental research, you will write project reports for your supervisor on a regular basis, write scientific papers and support grant writing.
You hold a doctoral degree (PhD) in Chemistry, Pharmaceutical Sciences or Engineering Sciences with experience in synthetic organic chemistry and/or medicinal chemistry;
Expertise in lead optimization process is an asset;
You did not reside, study or work in Belgium for more than 24 months in the 3 years immediately prior to the recruitment date (eligibility rule for postdoc with a subsidy);
Your academic qualities comply with the requirements stipulated in the university research policies;
You co-supervise PhD students;
You are quality-oriented, conscientious, creative and cooperative;
You have strong communication skills;
You are fluent in academic English (speaking and writing).