Postdoc for Protein Engineering: Focus on Development of Genetically Encoded Sensors

Postdoc for Protein Engineering: Focus on Development of Genetically Encoded Sensors

TUM - Technical University Munich

Munich, Germany

Genetically encoded sensors are a major tool to unravel the functioning of life on the cellular level. We are developing dedicated genetically encoded sensors for optoacoustics measurements. The candidate will focus on engineering chimeric proteins that show a small-molecule binding dependent change of photophysics. The candidate will further explore and exploit their intricate and exciting mechanisms and driving such proteins towards a use in life-science imaging applications. The projects will be very divers and include methods from protein-engineering and high-throughput screening over photo-physical and structural characterization to mammalian cell culture and eventual in vivo application. The work will be conducted in close collaboration with other laboratories of TUM and the Helmholtz Zentrum Muenchen (HMGU) that are leading in the respective research areas, e.g. in vivo application or protein structure elucidation. Hence, the position is an exciting interface between protein-engineering, basic photophysical research, development of molecular tools as well as imaging.

Qualification:

The successful applicant must have the following:

  • High motivation, curiosity, and commitment to scientific excellence
  • PhD Degree in Biology, Biochemistry, Chemistry or Physics
  • Background in chromophores, photophysics, photochemistry
  • Background in cell biology and molecular biology
  • Experience in protein engineering
  • Experience in high-throughput screening
  • Strong interest in imaging and optical spectroscopy techniques
  • Background in excited state photophysics, and photoisomerization processes will be appreciated as well as understanding of (protein-) environmental effects on the photophysical properties of chromophores
  • Background in fluorescent or chromophoric proteins will be appreciated
  • Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment
  • Excellent command of the English language

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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