Genetically encoded sensors are a major tool to unravel the functioning of life on the cellular level. We are developing dedicated genetically encoded sensors for optoacoustics measurements. The candidate will focus on engineering chimeric proteins that show a small-molecule binding dependent change of photophysics. The candidate will further explore and exploit their intricate and exciting mechanisms and driving such proteins towards a use in life-science imaging applications. The projects will be very divers and include methods from protein-engineering and high-throughput screening over photo-physical and structural characterization to mammalian cell culture and eventual in vivo application. The work will be conducted in close collaboration with other laboratories of TUM and the Helmholtz Zentrum Muenchen (HMGU) that are leading in the respective research areas, e.g. in vivo application or protein structure elucidation. Hence, the position is an exciting interface between protein-engineering, basic photophysical research, development of molecular tools as well as imaging.
The successful applicant must have the following: