Postdoctoral Fellow in Basic Malaria Research (100%)

Postdoctoral Fellow in Basic Malaria Research (100%)

Swiss TPH - Swiss Tropical and Public Health Institute

Basel, Switzerland

The Department of Medical Parasitology and Infection Biology (MPI) of Swiss TPH conducts basic and translational research in infection biology with a particular focus on infectious diseases affecting the global poor. The Malaria Host Interactions Unit (MHIU) at MPI is looking for an experienced researcher to join the team as a Postdoctoral Fellow in Basic Malaria Research (100%).

We are seeking a postdoctoral scientist to help us investigating how malaria parasites interact with their environment. We aim at understanding the molecular mechanisms intra-erythrocytic parasites employ to sense environmental changes and how this information is translated into cellular responses. The candidate will use the human malaria parasite Plasmodium falciparum to (i) identify and functionally characterize parasite-encoded as well as host cell-derived factors that control environmental sensing and (ii) identify downstream adaptation responses. Our group uses a diverse set of reverse genetics approaches (e.g. CRISPR/Cas9- and DiCre recombinase-mediated gene editing) in conjunction with state-of-the-art techniques for functional analyses (e.g. high content imaging, ChIP- and RNA-Sequencing, phosphoproteomics). The candidate will work on her/his own specific project as well as in close collaboration with other group members.

Supervised by Prof. Nicolas Brancucci, this position will be funded through a Swiss National Science Foundation (SNSF) Project Grant and is initially limited for up to three and a half years. The salary will be according to the regulations of the SNSF.

Main responsibilities include:

  • Generate transgenic P. falciparum parasite lines.
  • Generate transgenic red blood cells via manipulation of erythroid precursors.
  • Identify signalling pathways using phosphoproteomics approaches.
  • Test involvement of candidate factors in parasite environmental sensing using inducible knock-down and knock-out strategie.
  • Functionally analyse candidates using diverse molecular techniques.

You should have the following experience and skills:

  • Cell culture (mammalian and ideally P. falciparum or other protozoan parasites).
  • Molecular cloning and transfection.
  • Transcriptomics and (phospho-) proteomics techniques, incl. analysis.
  • Excellent command (speaking and writing) of English.

…and most importantly

  • Enthusiasm for studying malaria parasite biology.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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