Neutrophils are proinflammatory cells that are harmful for the host if their activation is not controlled as it is the case in inflammatory diseases. We have previously uncovered that the cytosolic Proliferating Cell Nuclear Antigen (PCNA) scaffold is a key regulator of neutrophil survival and radical oxygen species generation by the NADPH oxidase. We have also observed that the PCNA scaffold is dysregulated in neutrophils from patients with inflammatory disorders such as autoimmune vasculitis or rheumatoid arthritis.
Our goal is to understand the molecular interactions involving cytosolic PCNA that are crucial to control neutrophil activity and death pathways under physiological conditions and during inflammatory disorders.
Our research combines several in vitro approaches including structural biology, cell biology.We also use in vivo inflammation models to test and validate PCNA partners as potential therapeutic targets in neutrophils.
The project will address one of these topics and will be defined with the applicant according to his/her expertise and wishes.
Candidates will have a Ph.D. in immunology or biochemistry. She/he should have demonstrated success in a previous research experience in immunology or related fields testified by publications.
We expect the candidate to show autonomy and the ability to develop new projects in relation with the group leader and collaborators. Good English speaking, reading and writing skills will be essential