Applications are invited for a researcher to work on an MRC/Newton Fund/NAFOSTED- funded project aimed at creating an innovative targeted liposomal delivery system for the treatment of antibiotic resistant Helicobacter pylori infections.
Helicobacter pylori (Hp) infects half of the world's population and is the leading cause of gastric ulcers and cancer. While the prevalence has declined steadily in high income countries, due to appropriate hygienic standards and the existence of various first line or rescue therapies, it remains very high in low income countries. In many Asian countries, including Vietnam, gastric cancer is a leading cause of death. Additionally, there is a rising failure of drugs to eradicate Hp infections due to steadily increasing antimicrobial resistance. Important drugs commonly used for first line treatment of Hp, such as Metronidazole and Clarithromycin, are becoming obsolete in Vietnam. We are aiming to create an efficient drug delivery platform which can be used to combat the increasing resistance of Hp as the leading cause of gastric cancer in Vietnam (and elsewhere in low income countries).
The appointed researcher will work on an exciting new project in the context of an international collaboration between the University of Nottingham (UK), the 108 Military Central Hospital in Hanoi (Vietnam), and the Justus-Liebig- University of Giessen (Germany). Candidates must have excellent experience with recombinant protein expression and purification, standard molecular biology or biochemical techniques. Experience with functionalisation of liposomes is highly desirable. Experience with confocal laser microscopy is an advantage and/or specialised in vivo imaging techniques (e.g.Tc-99m NanoSPECT-CT imaging) is desirable.
In addition to the daily research activities, the appointed researcher will be responsible for facilitating information exchange between the collaborating centres, will be involved in organising and delivering a training school in Vietnam and will also coordinate and organise regular visits between the collaborating partners in the UK and Vietnam. Therefore, knowledge of the Vietnamese language is not only desirable, but an important advantage.
The researcher will be working with an academic at each of the research institutions to deliver the project.
Candidates must hold a PhD (or be near to completion), or equivalent in Chemistry, Biochemistry, Biology, Pharmacy, Pharmacology or related areas.