Applications are invited for a 2-years postdoctoral position in the field of RNA splicing in the laboratory SABNP / University of Paris-Saclay, France.
Candidate: The ideal candidate has a French and international research experience. He/she is an ambitious and highly motivated individual with interest in RNA biology, gene expression and data processing.
The research in our group aims at better understanding the mechanism of pre-mRNA splicing in mammals by combining molecular biology, bioinformatics and cell biology. In particular, our recent findings support the possibility that liquid-liquid phase separation contribute to splice site recognition (EMBO Rep (2019)20:e47604).
The successful applicant will uncover and study novel interactions among splicing factors through bioinformatics, biochemical and functional analyses. Tacking advantage of available RNA-seq datasets, the applicant will search for functional interactions by correlation analyses. The corresponding physical interactions will be further explored using biochemical techniques and in vivo analyses of splicing. These novel interactions are of potential importance to understand cell transformation driven by splicing factors mutations.