The team “Leukemia and niche dynamics” led by Diana Passaro is interested in exploring the mechanisms regulating cell-cell interaction in the bone marrow tissue during leukemogenesis. The vascularized BM tissue is a multicellular unit highly interconnected with the haematopoietic system in health and disease. How this unit participates into the development of acute leukemia is a fundamental missing piece of the puzzle. By combining cutting edge strategies such as intravital two-photon microscopy and tissue bioengineering, we aim at deciphering the role of specific mediators of this interaction in the context of acute leukemia.
We are seeking a candidate with a Master in molecular biology and related field with experience in cell cultures, cloning and genome editing. Experience in microscopy and mouse work is welcome but not mandatory.
The candidate will help in setting up the experimental protocols of the laboratory. He/She will be implicated in multiple projects directly supervised by the group leader. He/She will be in charge of in vitro preparations (cell cultures, cell primary cultures, organotypic cultures, patients’ samples) and intravital microscopy setting.