Generate and characterize human iPSC and mouse ESC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2/ADAT3 pathogenic variants; Assess cellular phenotypes (proliferation, cell cycle dynamics
Investigate how senescent cells shape tissue function in vivo, particularly its interplay with cellular plasticity/reprogramming, immune–stromal interactions, and tissue remodeling, including in physiological contexts such as female reproductive biology
You’ll work closely with other collaborative teams, bridging the gap between cell biology, genomics and pathogenesis. With your expertise in cell biology (cell culture of human primary cells), you will characterize the mechanisms of host-adaptation of