Postdoctoral Position in Cancer Neuroimmunology

Postdoctoral Position in Cancer Neuroimmunology

University of Basel

Basel, Switzerland

Our lab studies neuro-immune communication in cancer, with a particular focus on how peripheral neurons sense changes in tissue state and regulate immune-cell function. Emerging evidence suggests that neural signals can profoundly influence inflammation, immune surveillance, and tumour progression, yet the cellular and molecular mechanisms governing these interactions remain poorly understood.

Your position

The successful candidate will lead an ambitious interdisciplinary project at the interface of immunology, neuroscience, and cancer biology. The project will investigate how neural pathways regulate immune responses within tumours and how neuro-immune circuits can be manipulated to improve anti-tumour immunity.

Research directions may include:

• how peripheral sensory or autonomic neurons regulate dendritic-cell and T-cell function;
• neuronal sensing of inflammatory and tumour-derived signals;
• neuropeptide and neurotransmitter regulation of anti-tumour immunity;
• neural control of immune-cell trafficking, activation, and persistence within tissues;
• identification of neuro-immune signalling pathways that promote or restrain tumour growth;
• functional validation of new therapeutic targets at the neuro-immune interface.

Experimental approaches include in vivo tumour models, conditional mouse genetics, neuronal tracing, genetic and viral manipulation of neuronal populations, immune-cell depletion and adoptive transfer, spectral flow cytometry, cell sorting, imaging, transcriptomics, single-cell RNA sequencing, spatial transcriptomics, and functional neuro-immune assays.

Your profile

We are looking for a highly motivated experimental immunologist with a strong interest in neuro-immunology and tissue biology.

Applicants should have:

• a PhD in immunology, cancer immunology, neuroimmunology, molecular biology, or a related discipline;
• a strong conceptual and experimental background in immunology;
• substantial hands-on experience with in vivo mouse models;
• extensive experience with flow cytometry and immune-cell phenotyping;
• a strong record of experimental research, ideally including a high-quality first-author publication;
• the ability to design, execute, and interpret mechanistic experiments independently;
• strong scientific communication skills and the ability to work effectively in an interdisciplinary environment.

Experience in tumour immunology, dendritic-cell biology, T-cell biology, mouse genetics, peripheral neuroscience, neuronal tracing, viral vectors, single-cell genomics, spatial biology, or advanced imaging would be particularly advantageous.

Importantly, prior training in neuroscience is not required. Candidates with a strong immunology background who are excited to move into the emerging field of cancer neuroimmunology are strongly encouraged to apply.