Research Associate in In Vivo Genome Editing

Research Associate in In Vivo Genome Editing

University of Zurich

Zurich, Switzerland

Your responsibilities

• Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease required for the initiation of clinical trials;
• Administer genome-editing therapeutics and other test substances using relevant routes of delivery;
• Perform animal monitoring, blood and tissue collection, necropsies, organ harvesting and downstream sample processing;
• Perform molecular and cellular biology experiments, including mammalian cell culture, DNA and RNA isolation, PCR/qPCR, cloning and preparation of samples for sequencing;
• Analyse, interpret and document experimental results and contribute to the optimisation of experimental protocols;
• Maintain accurate records and ensure that all animal experiments are conducted in accordance with approved protocols and Swiss animal-welfare regulations;
• Collaborate closely with scientists, students and external project partners across several parallel research projects.

Your profile

• BSc or MSc in molecular biology, biotechnology, biomedicine, veterinary medicine, pharmaceutical sciences or a related discipline;
• Substantial hands-on experience conducting experiments with mice is essential;
• Candidates should be confident in animal handling and in relevant experimental procedures such as dosing/injections, monitoring, blood sampling, tissue collection and necropsy;
• Strong practical experience in molecular and cellular biology (cloning, cell culture) and careful handling of biological samples;
• Experience with CRISPR genome editing, RNA therapeutics, lipid nanoparticles, viral vectors, liver biology or metabolic disease models is an advantage but not required;
• Ability to organise and conduct experiments independently, troubleshoot procedures and contribute effectively to multiple projects;
• A highly reliable, precise and collaborative working style, with strong attention to animal welfare and experimental documentation;
• Good written and spoken English.