Postdoc - Targeting Allergic Hypersensitivity

Postdoc - Targeting Allergic Hypersensitivity

University of Basel

Basel, Switzerland

The Wymann lab at the DBM Mattenstrasse, University of Basel, Switzerland, invites qualified candidates to apply for a post-doctoral position in Biomedical Research investigating allergic, immunologic and metabolic processes. The candidate will join a multi-disciplinary team focusing on the elucidation and targeting of major stress and lipid kinase signaling pathways in allergic hypersensitivity, allergy, chronic inflammation and cancer. Besides performing biochemical, cellular and mouse genetic studies, the candidate interacts with Chemists developing novel bioactive small molecules targeting relevant signaling nodes in the mentioned pathologies.

Project

The aim of the project is to elucidate molecular intra- and extracellular mechanisms of signaling modulating myeloid cells' immune responses. The project is supported by Innosuisse and has a translational goal aiming to pave a path to clinical applications.

This project is flanked by basic research projects:

• investigating of the role of phosphoinositide 3-kinase (PI3K) signaling in allergy, metabolic control, obesity, diabetes and cancer;
• developing and validation of novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism.

Your position

• Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network;
• Functional immune cell/phenotypic/response output assays and biomarker detection/identification in vitro and in vivo;
• Determining immune cell responses via FACS, high content imaging microscopy, proteomics and transcriptomics and more;
• Identification of targetable signaling nodes in the above pathways;
• Set-up of in vitro and in vivo validation workflows for novel small molecules;
• Writing of scientific publications, patents and regulatory reports;
• Personal career and leadership development, mentoring of students and collaborators.

Your profile

The successful candidate holds a PhD in Biochemistry, Molecular Biology, Immunology or another relevant Life-Science degree. Expertise in immunology, allergy, FACS (analysis and cell sorting), and mouse models is required. The candidate should hold a LTK module 1 (rodent course, Switzerland) or a FELASA function A/C/D (EU) certificate, including the required associated continued formation.

The candidate has an excellent proven track record in the publication of peer-reviewed scientific articles and/or patents.