Postdoc Position in Clinical Immunopeptidomics and Proteomics

Postdoc Position in Clinical Immunopeptidomics and Proteomics

Utrecht University - Faculty of Science

Utrecht, Netherlands

€ 3.546 - € 5.538 per month gross

Your job

As a Postdoctoral Researcher in the group of dr Marino, you will play a central role in advancing the group's research through the development and application of state-of-the-art immunopeptidomics/proteomics workflows for antigen identification, quantification, and validation. Your work will directly contribute to translational and precision medicine initiatives, with a particular focus on the discovery of clinically relevant targets for cancer immunotherapy.

In this role, you will support the team by driving mass spectrometry-based method development and contributing your expertise to a range of proteogenomics and immunology-related projects. Beyond providing technical leadership, you will proactively introduce innovative ideas, establish new research directions, and spearhead initiatives that strengthen the group's scientific capabilities.

You will have the opportunity to make a significant impact by developing novel workflows that enable the identification, accurate quantification of antigens and associated mechanisms of T-cell recognition. These discoveries will support the development of next-generation vaccine-based therapies, ultimately contributing to improved outcomes for patients with cancer.

Finally, you will be involved in many different multicentered and multidisciplinary collaborations, with both industry as well as academia and medical institutes. This will increase your exposure and expand your own professional network supporting your future scientific career.

Key Responsibilities

• Design and execute mass spectrometry–based workflows for the identification and quantitation of disease-associated antigens from clinical specimens;
• Develop, optimize, and apply DIA- and PRM-based proteomics methods;
• Perform quantitative data analysis, normalization, quality control, and statistical interpretation of proteomics datasets;
• Contribute to biomarker and antigen validation studies across diverse clinical cohorts;
• Collaborate closely with clinicians, computational biologists, and translational researchers;
• Support method development, data interpretation, manuscript preparation, and grant writing.

Your qualities

Required qualifications and experience

• PhD in Proteomics, Analytical Chemistry, Biochemistry, or a related field;
• Proven hands-on experience with mass spectrometry–based proteomics and/or immunopeptodomics in clinical or translational research settings;
• Demonstrated expertise in:
  • Data-Independent Acquisition (DIA);
  • Parallel Reaction Monitoring (PRM);
  • Quantitative proteomics workflows;
  • Data normalization and quality control strategies.
• Strong experience in processing and interpreting complex MS datasets;
• Track record of peer-reviewed publications in relevant fields;
• Excellent communication and teamwork skills.

Preferred qualifications and experience

• Structural biology and cross-linking mass spectrometry;
• Workflow automation and reproducible data analysis pipelines.