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Design and execute CRISPR-knockout (CRISPR-KO) and CRISPR-mediated base editing screens to investigate novel targets and biomarkers in cancer immunity. Perform experimental approaches to study DNA damage response (DDR) pathways and their role in
Generate and characterize human iPSC and mouse ESC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2/ADAT3 pathogenic variants; Assess cellular phenotypes (proliferation, cell cycle dynamics