Postdoctoral Researcher in Structural Biology

Postdoctoral Researcher in Structural Biology

Uppsala University - Department of Cell and Molecular Biology

Uppsala, Sweden

Project description

The postdoctoral researcher will investigate fundamental mechanisms that govern the organization and maintenance of chromatin. This project offers a unique opportunity to apply state-of-the-art cryo-electron microscopy, together with biochemical and biophysical approaches, to uncover how chromatin-associated molecular machines interact with, remodel, and regulate the genome. The successful candidate will work at the interface of structural biology, molecular biology, and biochemistry to address key questions in chromatin architecture and genome regulation.

The postdoctoral researcher will join a vibrant structural biology environment within the department, with excellent access to state-of-the-art cryo-EM facilities, technical expertise, and infrastructure.

Requirements

We are seeking a highly motivated candidate with a PhD in structural biology, biophysics, biochemistry, molecular biology, or a related field. Applicants must have prior experience in structural biology, such as cryo-electron microscopy, X-ray crystallography, NMR spectroscopy, integrative structural biology, or related approaches. The PhD degree must be obtained by the time the employment decision is made. In accordance with eligibility requirements, priority will be given to candidates who obtained their PhD no more than three years before the application deadline. The three-year period is calculated from the application deadline and may be extended in cases of documented special circumstances, including sick leave, parental leave, or duties in labour unions.

The candidate should be able to work independently and must have excellent proficiency in English, as the position is based in an international research environment. We value strong collaborative skills, self-motivation, scientific curiosity, and a genuine interest in basic research, particularly in addressing fundamental biological questions through structural, biochemical, and quantitative approaches.

Additional qualifications

Experience with cryo-electron microscopy, in vitro biochemical reconstitution, and biophysical analysis is highly valued. Experience with protein purification, protein-DNA complexes, chromatin or nucleosome-based systems, cryo-EM sample preparation, data processing, structure determination, or complementary biophysical methods will be considered an advantage.