Postdoctoral Position in Pharmacometrics

Postdoctoral Position in Pharmacometrics

Uppsala University - Department of Pharmacy

Uppsala, Sweden

Duties

The research concerns development of a natural history pharmacometrics framework for Autosomal Dominant Polycystic Kidney Disease (ADPKD), an inherited genetic kidney disorder, to support development of new drug therapies for this inherited genetic kidney disorder. ADPKD is characterized by progressive renal cyst growth and kidney enlargement, decline in eGFR and requirement for renal replacement therapy. The framework development will be based on several longitudinal real world data bases including both traditional and newly derived covariates, biomarkers and endpoints of relevance for the disease. The research offers a possibility to mechanism-based model development utilizing non-linear mixed effects models for predicting disease trajectories and the population and individual level, supporting decisions on treatment options and trial designs. The project will be performed in international collaboration with multi-disciplinary experts (clin pharm, pharmacometrics, biostats and imaging) of our industrial partner. The candidate is expected to take a leading role in the collaborative meetings and will be involved in writing scientific publications and part in the dissemination of research findings nationally and internationally.

Requirements

PhD degree in pharmacometrics or a related field or a foreign degree equivalent to a PhD degree in the specified field. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.

We place great emphasis on personal suitability and interest in the areas of pharmacometrics and mechanism-based modeling. The applicant should have good collaboration and communication skills, with ability to express him/herself well, in both oral and written English. A demonstrated capability to conduct and complete a scientific project in a structured and methodological manner is required. Experience of programming in R and pharmacometrics software such as NONMEM or Monolix.

Additional qualifications

Prior experience of real-world data research and disease trajectory modelling is advantageous. Interest and skill in scientific writing is highly desirable, as is experience of working in an international environment.