Postdoctoral Fellow at the Cancer Dormancy & Immunity Lab

Postdoctoral Fellow at the Cancer Dormancy & Immunity Lab

Champalimaud Foundation

Lisbon, Portugal

The Cancer Dormancy & Immunity lab headed by Ana Luísa Correia is seeking a highly motivated postdoctoral candidate to join us on a project supported by a La Caixa Health Research Grant (DynaMet, HR24-00648).

The overarching goal of this project, DynaMet, is to uncover the composition and dynamics of organ-specific microenvironments that support or oppose breast cancer metastasis in two of the most common target sites, liver and bone, and leverage these insights into novel anti-metastatic therapeutic strategies.

The selected candidate will specifically focus on elucidating the dynamics of stromal-immune interactions during the formation of liver metastases. The project will build on a body of preliminary data from single-cell and spatial profiling technologies in mouse and human tissues to identify key effectors of the stromal-immune crosstalk within the liver spatial context, and test their functional relevance using cell-type specific targeting in vivo.

DynaMet is financed as a consortium with Neta Erez’s group (Tel Aviv University, Israel). The successful candidate will benefit from the synergistic expertise of the consortium and interaction with these two excellent groups doing pioneering research in metastasis.

Skills/Qualifications

Minimum qualifications

• PhD in Cell and Molecular Biology, Biochemistry, Biomedical Engineering, Biomedicine, Immunology or Cancer Biology, and a strong interest in tumor microenvironment.

Specific Requirements

• Extensive experimental laboratory experience, including experience with cell culture, molecular biology, and biochemistry.
• Experience with imaging-based techniques, multicolor cell phenotyping by flow-cytometry, and aptitude for animal studies.
• Proven track record in conducting research, including designing, executing, and interpreting experiments, as demonstrated by previous publications (with at least one first author publication).
• Ability to prioritize and see the big picture, but also to focus on details.
• A collaborative mindset and motivation to work at an international and interdisciplinary environment.

Languages

• English, Excellent.