The host laboratory has previously uncovered a signaling pathway in the plant wound response that relies on damage-activation of metacaspases and cleavage of immunomodulatory signaling peptides (doi/10.1126/science.aar7486). Proteolysis is a powerful regulatory mechanism that generates novel protein fragments (proteoforms) with specialized biological functions. In plants, proteolysis is emerging as a key regulator of immune and wound responses, yet the global landscape and evolutionary conservation of protease-mediated cleavage events remain poorly understood. Chloroplast proteins are particularly attractive candidates due to their high abundance, deep evolutionary conservation, and central role in plant immunity through defense signaling and retrograde communication with the nucleus. This position offers a strong opportunity to expand advanced computational and integrative (proteo-)omics expertise in the lab, guided by leading experts in terminomics, systems-level data analysis, and structural bioinformatics.
A postdoctoral position is a career-building opportunity for early-career researchers, so we are primarily looking for a candidate who earned their Ph.D. no more than three years ago.