Scientist II Purification (Pilot)

Scientist II Purification (Pilot)

Evotec

Toulouse, France

What You’ll Do:

Pilot-Scale Operations & Execution:

• Execute and support pilot-scale downstream unit operations, including bioreactor runs up to ~50 L, for engineering, scale-up, and material generation batches;
• Translate laboratory-scale downstream process parameters into pilot-scale execution under guidance, ensuring process robustness, reproducibility, and data integrity;
• Support pilot activities that bridge process development and cGMP manufacturing, including preparation for tech transfer.

Study Support & Cross-Functional Collaboration:

• Collaborate closely with USP pilot, DSP development, Analytical, and Manufacturing teams to support pilot-scale material generation for process characterization, equipment qualification, and other material generation (e.g., toxicology, stability);
• Participate as an downstream pilot representative on cross-functional project teams, contributing to planning and execution aligned with project timelines.

Facility & Operational Readiness:

• Support day-to-day pilot operations, including equipment setup, preparation, cleaning, and turnover;
• Ensure activities are conducted in compliance with safety, quality, and operational standards;
• Assist with scheduling and readiness activities in coordination with senior team members.

Pilot Optimization & Technology:

• Support the implementation and optimization of intensified or advanced upstream processes at pilot scale, including the use of single-use systems and automation tools;
• Collect, review, and interpret pilot-scale process data to support process understanding and improvement.

Documentation & Compliance:

• Accurately document pilot operations, process data, and observations in batch records, protocols, and reports;
• Author and review SOPs, protocols, and technical reports under guidance;
• Support deviation documentation and investigations as needed.

Technical Contribution & Knowledge Sharing:

• Act as a technical contributor for downstream pilot execution, including scale-up principles and process control strategies;
• Support preparation of tech transfer documentation to manufacturing;
• Communicate pilot study objectives, execution status, and results clearly to project teams and management.

Training & Team Support:

• Support training of junior staff and technicians on pilot-scale DSP operations, safety practices, and standard procedures;
• Promote a strong culture of safety, data quality, and scientific rigor.

Vendor & Equipment Support:

• Support interactions with equipment vendors and engineering teams for equipment setup, troubleshooting, and optimization.

Your profile:

• Master’s in engineering, Biochemistry, Biology, or related field with 5+ years of experience or Ph.D. in Engineering, Biochemistry, Biology, or related field. Bachelor's with more than 10 years of experience;
• Proficiency in both verbal and written English is essential;
• Excellent attention to detail, able to stay organized and relaxed in complex situations while keeping track of multiple tasks and data;
• Experience in pilot-scale operations (10–200 L upstream scale);
• Understanding of scale-up principles, process control, and data interpretation for both upstream and downstream processes;
• Experience supporting engineering batches, material generation, and technology transfer to cGMP manufacturing;
• Proven ability to lead multidisciplinary teams, manage pilot facilities, and coordinate cross-functional projects;
• Experience in biosimilar or biologics development programs is an advantage;
• Experience working in or supporting a cGMP or cleanroom environment;
• Familiarity with process and equipment qualification (IQ/OQ/PQ);
• Understanding of process safety and risk assessment principles in pilot-scale bioprocessing.

Pluses

• General understanding of cell culture, protein chemistry, and bioprocess engineering fundamentals.