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This programme of research will investigate candidate pathophysiological mechanisms of susceptibility in takotsubo cardiomyopathy. Specifically, the work of the appointee will focus on (1) the activation of innate and adaptive immunity
Generate and characterize human iPSC and mouse ESC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2/ADAT3 pathogenic variants; Assess cellular phenotypes (proliferation, cell cycle dynamics
Experimental research to understand microbial behaviour in confined spaces (synthetic hydrogels) and dynamic environments using imaging, microfluidics and molecular biology methods; Scientific cooperation with researchers
The project will involve developing platform approaches for pharmacokinetic (PK)- pharmacodynamic (PD) modelling (pharmacometrics) -based applications in oncology, including quantification of relationships between longitudinal tumor size
In this project you will use follow up on datasets exposing complex cell states when cells try but fail to mature. You will work to validate these cell states and identify key regulators, testing them using genetic approaches. We are looking for a