Postdoctoral Research Fellowship in Precision Medicine for Glioblastoma

Postdoctoral Research Fellowship in Precision Medicine for Glioblastoma

IEO - European Institute of Oncology

Milan, Italy

Project Overview:

Glioblastoma (GBM) is among the most lethal human cancers, marked by extreme heterogeneity and poor prognosis. Despite decades of research, current treatments remain largely ineffective, and patient survival rarely exceeds two years. A major barrier to clinical progress lies in the challenge of identifying robust, actionable molecular targets within such a diverse and evolving disease landscape.

To address this, our team has developed an advanced drug screening (ADS) platform that leverages patient-derived preclinical models, including both in vitro cultures and in vivo systems. This platform enables systematic evaluation of therapeutic responses and resistance mechanisms.

The ADS approach is complemented by multi-omics analyses, encompassing genomic, transcriptomic, and epigenetic profiling, to uncover the molecular determinants of GBM heterogeneity and treatment resistance.

Together, these integrated methodologies aim to accelerate the translation of personalized medicine into effective therapeutic interventions for GBM patients.

Responsibilities:

The selected postdoctoral fellow will be responsible for:

• Establishing and molecularly characterizing patient-derived glioblastoma models (in vitro and in vivo);
• Applying and optimizing the advanced drug screening workflow;
• Generating, analyzing, and interpreting multi-omics datasets (genomic, transcriptomic, and epigenetic);
• Contributing to data integration and translational interpretation within a multidisciplinary research team.

Candidate Profile:

We are seeking a highly motivated, independent, and collaborative researcher with:

• MA degree in Biology, Biotechnology, Pharmacology, Veterinary, Medicine or relative disciplines awarded by an Italian university or a title obtained abroad which has been recognized as equivalent to the Italian degree;
• PhD in Biology, Biotechnology, Oncology, Genetics, Pharmacology, Molecular Medicine or relative disciplines;
• a strong background in stem cell biology, molecular biology, cancer biology, or related fields;
• demonstrated experience in multi-omics approaches, particularly transcriptomic and epigenomic dataset analysis and interpretation (considered a significant asset);
• a solid publication record, including at least one first-author paper in medium/high-impact peer-reviewed journals;
• strong communication skills and the ability to work in an interdisciplinary and international environment.