Medical Director CNS

Medical Director CNS

ProQR Therapeutics

Leiden, Netherlands

Our Development department is currently looking for a Medical Director CNS (Full-time) to join our team.

The Development Department advances drug candidates from early research into clinical testing, ensuring they are thoroughly evaluated for safety and efficacy. Translational Development generates the data needed to move programs into the clinic, while Clinical Development designs and executes trials to demonstrate safety and efficacy in patients. Together, they connect science, medicine, and regulatory strategy to drive successful therapeutic development.

The Medical Director CNS serves as a strategic and scientific leader within Clinical Development, driving the advancement of ProQR’s pipeline and contributing to improved patient outcomes. As a subject matter expert in CNS diseases, the Medical Director provides deep scientific and clinical input into the design, execution, analysis, and reporting of Phase I–III clinical studies. The role also supports regulatory submissions and preparation for commercial launch, while partnering cross-functionally to ensure high-quality development strategies. In addition, the Medical Director offers clinical insight to research teams on an ad-hoc basis, helping translate scientific discoveries into impactful therapeutic programs.

We expect our Medical Director CNS to have:

• MD (or equivalent) required; board certification in neurology, psychiatry or related CNS specialty required;
• Minimum 5+ years of experience in the biotechnology or pharmaceutical industry, with a proven leadership role in clinical development or related functions, including responsibility for the design, execution, analysis, and reporting of early- and/or late-phase clinical trials;
• Deep understanding of CNS disease biology, clinical trial methodology, biostatistics, and global regulatory requirements relevant to CNS drug development;
• Demonstrated expertise in CNS disorders, including an advanced understanding of CNS biomarker strategy and development (e.g., imaging, fluid biomarkers, digital biomarkers);
• Proven ability to foster effective cross-functional collaboration within global project teams and clinical study teams, with a focus on operational excellence and timely execution;
• Strong scientific and clinical network within the CNS community, including key opinion leaders, investigators, academic centers, and patient advocacy partners;
• Ability to build and maintain relationships with external stakeholders, including key opinion leaders, investigators, clinical sites, patient organizations, and CROs;
• Excellent leadership, communication, strategic thinking, and analytical problem-solving skills, with the ability to influence and guide cross-functional decision-making;
• Exceptional verbal and written communication skills in English, including experience representing clinical programs to internal leadership, external experts, and regulatory bodies;
• Proficiency in scientific/medical literature interpretation, clinical data analysis, and the use of digital and statistical tools relevant to clinical research.

Skills and competencies that are required for making the difference:

• Highly organized, analytical and detail-oriented;
• Able to work in an ambitious, fast-paced environment;
• Team-player;
• Strong project planning and management skills, with outstanding written and verbal communication skills;
• Creative and Critical thinker, with decision-making and problem-solving skills;
• Pro-active and pragmatic self-starter, with a result-oriented mindset;
• Excellent knowledge of spoken and written English.