Postdoctoral Fellow SMIS Beamline

Postdoctoral Fellow SMIS Beamline

SOLEIL Synchrotron

Saint-Aubin, France

Context and Missions

The postdoctoral fellow will participate in the beamline's missions under the supervision of Christophe Sandt and in collaboration with Hélène Bertrand (full professor, Département de chimie de l’ENS-PSL/CNRS/Sorbonne Université).

The 2-year postdoctoral position is funded by ANR under ‘POPCORN’ project.

The postdoctoral fellow will participate in the research project ‘Dual Organometallic Platforms with Advanced Optical Imaging for Enhanced Anti-Inflammatory Therapies’ (POPCORN). The project aims to design new carbon monoxide releasing molecules (CORMs) with reduced-toxicity to be used as anti-inflammatory agents.

The postdoctoral fellow will work with the PhD student recruited for the POPCORN project and in collaboration with Gabriel David and Antonella Najjar from SOLEIL microfluidic laboratory.

The main goal of the postdoctoral position is to experimentally develop and refine a microfluidic device compatible with IR microspectroscopy to be used to measure living, fully-hydrated cells. The microfluidic device will be used in conjugation with the synchrotron source to follow CO release kinetics from living cells treated with the newly developed CORMs. An existing in-house developed microfluidic device is available at SMIS. The project aims to further refine the device to improve its reliability and usability, and to allow for measurement of longer kinetics. The candidates will eventually be able to develop other research projects.

The candidate will assist the beamline team in helping the external user teams (setting of the beamline, installation of the sample environment, support to the users during their experiment time).

The candidate will help with infrared microspectroscopy data analysis.

Profile

The candidate should have a PhD degree, or equivalent qualification, in analytical chemistry, chemistry, materials science, cell biology or in a related discipline.

The candidate should have strong experimental skills, including data processing.

The candidate should demonstrate:

• expertise in microfluidics;
• expertise in microscopy;
• expertise in spectroscopy;
• expertise in data analysis.

Training in cell biology or eukaryotic cell cultivation methods, programming skills, and expertise in microfluidic dedicated to IR spectroscopy will be considered strong advantages.

The candidate must be fluent in French or English.