Postdoctoral Research Associate - Subcellular Relocalization of the Water Channel, Aquaporin 4

Postdoctoral Research Associate - Subcellular Relocalization of the Water Channel, Aquaporin 4

Aston University

Birmingham, United Kingdom

The successful candidate will be funded by Professor Bill's ERC Advanced Grant, which investigates how the subcellular relocalization of the water channel, aquaporin 4, dynamically regulates glymphatic clearance. When glymphatic clearance is impaired, toxic waste products can accumulate within brain tissue leading to conditions such as Alzheimer’s and Parkinson’s diseases; worldwide over 55 million people currently live with dementia and there is no cure.

The focus of the candidate’s work within the ERC project will be to build a controlled microenvironment in the form of a gliovascular interface on a chip in order to make detailed measurements of glymphatic regulation using advanced imaging techniques.

The successful candidate will have completed a PhD or a PhD near completion in cell biology, bioengineering, bioscience, molecular biology or a related field. Candidates should have extensive experience of working with microfluidic chips, mammalian cell culture and advanced imaging techniques.