Postdoc Position in Epigenome Engineering

Postdoc Position in Epigenome Engineering

Utrecht University - Faculty of Science

Utrecht, Netherlands

Chemical modifications of histones and DNA provide an important regulatory layer for gene expression control and numerous other processes in the cell. In this context, individual and combinatorial modifications guide spatiotemporal recruitment of regulatory factors to specific regions in the genome. Despite many efforts to characterise chromatin-mediated regulation of gene activity, the direct involvement of chromatin marks in instructing transcriptional outcomes remains unclear and requires further investigation.

Your job

This project aims to bridge chromatin engineering and epigenomics to study epigenetic regulation of transcriptional processes. Potential approaches will involve manipulation of epigenetic marks in embryonic stem cells, investigating changes in epigenetic landscapes and transcription upon controlled manipulation, and/or engineering of synthetic chromatin states. You are encouraged to bring in your individual ideas and expertise to the current project and furthermore to develop new project ideas.

Your qualities

You are dedicated scientist with a background in chromatin biology and/or gene regulation and experience in cell engineering, molecular cloning, genomics, and computational data analysis workflows. In addition you:

• have obtained, or are on track to obtain, a PhD with first or co-author publications/preprints in the respective field;
• you are able to work independently as well as collaboratively in a team;
• demonstrate strong written and oral communication skills in English.