Postdoctoral Researcher - Covalent Chaotropic Membrane Transport for Biotherapeutic Delivery

Postdoctoral Researcher - Covalent Chaotropic Membrane Transport for Biotherapeutic Delivery

Constructor University

Bremen, Germany

We are offering a Postdoctoral position in the Nau research group, to contribute to the innovative project CARAMEL Covalent Chaotropic Membrane Transport for Biotherapeutic Delivery, as a part of a dynamic international team embedded within a Synergy Grant funded by the European Research Council.

Project overview

The CARAMEL project aims to pioneer new synthetic strategies for modified boron clusters that interact with biological membranes, enabling efficient transport of therapeutics across these barriers. This interdisciplinary research combines organic synthesis, supramolecular chemistry, and membrane biophysics.

Job description

You will contribute to the following tasks within the project framework:

• Design and perform multi-step synthesis of novel boron cluster derivatives, including purification and comprehensive structural characterization;
• Investigate their interactions with model cellular membranes, including liposomes of varied compositions, using physico-chemical techniques;
• Mechanistic studies of membrane transport, employing advanced fluores-ence-based assays.

Your profile

We are looking for a highly motivated early-stage researcher with:

• A PhD in Chemistry, Biochemistry, or related field;
• Strong expertise in synthetic chemistry and molecular characterization (NMR, LC-MS, HPLC, UV-vis, and fluorescence spectroscopy);
• Knowledge on supramolecular chemistry;
• Hands-on experience in membrane transport studies would be advantageous;
• Excellent communications skills in English, both written and spoken;
• A collaborative spirit, strong organizational and time-managing abilities, and problem-solving skills.