Biochemistry Research Associate - Protein Biochemistry

Biochemistry Research Associate - Protein Biochemistry

Pierre Fabre

Toulouse, France

Your mission

We are seeking for a talented and highly motivated Biochemistry Research Associate to join our Oncology Drug Discovery team and support our small molecule/antibody identification and characterization efforts.

The ideal candidate will have relevant experience in the pharmaceutical/biotech industry, with sound hands-on expertise in designing, executing and interpreting “gene-to-protein” experiments with state-of-the-art molecular biology and protein biochemistry techniques.

Key Responsibilities

• Design protein constructs for structural and functional characterization purposes;
• Generate vectors for heterologous recombinant protein expression in bacteria, insect- and mammalian cell hosts;
• Develop and optimize methods for protein extraction, purification, characterization and quantification with a high level of independent critical thinking;
• Characterize protein biomolecular interactions in support to target discovery and validation efforts by the target discovery and enablement teams;
• Ensure high-quality data generation, analysis, and timely report to project teams;
• Leverage lab automation to improve assay operation, quality, and overall productivity;
• Properly document experimental design, findings, and protocols and comply with all laboratory training and safety requirements;
• Collaborate with multi-disciplinary project teams and communicate scientific/technical contributions to deliver on project goals in relevant meetings;
• Establish relationships and coordinate collaborations with vendors, external partners and CROs to achieve high standards of productivity and quality, extend internal capabilities and optimally serve project needs;
• Drive scientific and technical innovations to develop and enhance functional capabilities.

Who you are?

Qualifications, Experience and Skills

• MSc in Biochemistry, Biophysics or related field with 5+ years’ relevant experience in a biotech/pharmaceutical setting (or recent Ph.D. with significant exposure to drug discovery);
• Demonstrated hands-on proficiency in a wide range of protein expression systems;
• Hands-on experience with protein extraction and purification methods (e.g. cell lysis, ultracentrifugation, dialysis, liquid chromatography);
• Working knowledge of techniques for the characterization of protein-protein and protein-ligand interactions (e.g. thermal unfolding/denaturation, light scattering, analytical ultracentrifugation, structural MS);
• Proficiency with relevant data processing analysis and visualization software tools;
• Expertise with protein structural characterization (e.g. X-ray crystallography, NMR,…) and knowledge on adjacent disciplines (e.g. assay development) are highly desired;
• Experience in oncology is a plus;
• Motivated and agile team player with the ability to work in a collaborative environment across the R&D organization;
• Excellent verbal, and written communication skills in English are essential.