Precision Medicine Biomarker Senior Scientist

Precision Medicine Biomarker Senior Scientist

argenx

Ghent, Belgium

We are seeking a highly motivated Senior Scientist with expertise in immunology research and biomarker data analysis to join our Translational Science team. The successful candidate will play a key role in supporting and leading biomarker strategies, enabling stratified medicine/diagnostic approaches, and advancing the probability of successful drug development and approval.

Main responsibilities

Biomarker Strategy & Implementation

• Drive precision medicine strategies while leveraging assay technology expertise, technical knowledge, disease understanding, and patient needs;
• Participate in the selection, development, and validation of predictive, pharmacodynamic, and safety biomarkers, including biomarkers supporting treatment response, disease understanding and Mode-of Action;
• Translate biomarker context of use (COU) into analytical requirements and ensure fit-for-purpose assay and vendor selection;
• Drive the implementation of biomarker assays and sample analysis, collaborating with internal and external teams, including omics approaches;
• Act as an interactor between biomarker and translational scientists, ensuring alignment of biomarker strategies with translational research objectives;
• Collaborate closely with Medical Affairs and Commercial teams to ensure biomarker insights support clinical positioning and market access strategies;
• Contribute to reverse translation efforts, using clinical data to inform preclinical research and future biomarker development.

Biomarker Data Analysis & Interpretation

• Support Biomarker Data Science team to ensure data is analysed in line with COU, assay capabilities and clinical development strategy;
• Contribute to the FAIRification of biomarker data and their metadata;
• Collaborate with cross-functional teams to integrate biomarker findings into drug discovery and development decisions, including patient selection and dose optimization;
• Act as a liaison between scientific teams and data scientists during statistical analysis plan (SAP) development, ensuring research questions and objectives are accurately reflected;
• Gather and clarify requirements from scientists and stakeholders for data scientists and statisticians;
• Interpret analysis results provided by statisticians or data scientists and partner to summarization of key findings;
• Prepare clear, scientifically robust reports and presentations of insights and implications of results to scientific internal stakeholders, regulatory submissions, and external publications.

Innovation & Framework

• Support the build and maintenance of data storage solutions for translational activities and ensure compliance with FAIR data principles;
• Stay current with emerging technologies, analytical methods, and regulatory guidance in biomarker research;
• Contribute to the implementation of novel data analysis and biomarker identification approaches, including machine learning and AI-driven strategies for biomarker discovery;
• Identify opportunities to streamline workflows and improve data quality, supporting operational excellence.

Professional experience/expertise

• PhD in Immunology, Molecular Biology, with knowledge of Bioinformatics, Computational Biology, or Biostatistics (or equivalent experience);
• Strong understanding of clinical or research study design principles;
• Experience collaborating with statisticians and data scientists;
• Proven ability to interpret statistical outputs of biomarker data and to clearly communicate findings;
• At least 3 years of relevant research/industry experience in biomarker strategy and data analysis;
• Proven track record in innovative science, publications, and impact on development and decision making;
• Experience in disease areas aligned to argenx’s immunology-focused ambitions;
• Proficiency in biomarker data and statistical analysis, including omics;
• Excellent written and verbal communication skills;
• Experience with biomarker data analysis and regulatory requirements (GCP/GCLP).

Profile

• Profound medical/scientific knowledge, especially in immunology;
• Team player, motivated, enthusiastic, accurate, and resilient;
• Strong project, organizational, and interpersonal skills;
• Excellent communication skills in English (written and oral);
• Ability to adapt to changing priorities and work effectively on multiple programs in a fast-paced environment;
• Capable of collaborating with internal and external stakeholders.