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This programme of research will investigate candidate pathophysiological mechanisms of susceptibility in takotsubo cardiomyopathy. Specifically, the work of the appointee will focus on (1) the activation of innate and adaptive immunity
The successful candidate will lead an ambitious interdisciplinary project at the interface of immunology, neuroscience, and cancer biology. The project will investigate how neural pathways regulate immune responses within tumours and how neuro-immune
The project will investigate how tissue stiffness, extracellular matrix composition, mechanosensitive signaling proteins regulate neuron–glioma interaction and tumor proliferation. The broader goal is to identify therapeutic vulnerabilities that arise
The aim of the project is to elucidate molecular intra- and extracellular mechanisms of signaling modulating myeloid cells' immune responses. The project is supported by Innosuisse and has a translational goal aiming to pave a path to clinical
Design and perform genetic and genomics screens to reconstruct maps of functional interactions across the ERN; Design and carry out functional experiments to mechanistically dissect the basis of identified interactions; Identify physiologically relevant