Postdoc - Targeting Allergic Hypersensitivity

Postdoc - Targeting Allergic Hypersensitivity

University of Basel - Department of Biomedicine

Basel, Switzerland

Project

The aim of the project is to elucidate molecular intra- and extracellular mechanisms of signaling modulating myeloid cells' immune responses. The project is supported by Innosuisse and has a translational goal aiming to pave a path to clinical applications.

This project is flanked by basic research projects
 i) investigating of the role of phosphoinositide 3-kinase (PI3K) signaling in allergy, metabolic control, obesity, diabetes and cancer; ii) developing and validation of novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism.

Your position

• Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network;
• Functional immune cell/phenotypic/response output assays and biomarker detection/identification in vitro and in vivo;
• Determining immune cell responses via FACS, high content imaging microscopy, proteomics and transcriptomics and more;
• Identification of targetable signaling nodes in the above pathways;
• Set-up of in vitro and in vivo validation workflows for novel small molecules;
• Writing of scientific publications, patents and regulatory reports;
• Personal career and leadership development, mentoring of students and collaborators.

Your profile

The successful candidate holds a PhD in Biochemistry, Molecular Biology, Immunology or another relevant Life-Science degree. Expertise in immunology, allergy, FACS (analysis and cell sorting), and mouse models is required. The candidate should hold a LTK module 1 (rodent course, Switzerland) or a FELASA function A/C/D (EU) certificate, including the required associated continued formation.

The candidate has an excellent proven track record in the publication of peer-reviewed scientific articles and/or patents.