Junior Postdoctoral Position in Innate Immunity

Junior Postdoctoral Position in Innate Immunity

Institut Pasteur

Paris, France

Dr. Nicolas Serafini’s group studies group 3 ILC (ILC3) biology, particularly in the context of bacterial infection and cancer. After being awarded an ANR funding, his team, which belongs to the Innate Immunity Unit, headed by Prof. James Di Santo, is looking for a junior post-doctoral researcher.

ILC3s promote the intestinal barrier integrity through the containment of beneficial commensal bacteria. These resident immune cells monitor environmental signals by scanning tissues and producing inflammatory cytokines that serve to counteract invading pathogens and preserve intestinal homeostasis. Interestingly, ILC3s also exhibit ‘memory-like’ properties that enhance their protective functions. Despite their presence in intestinal lesions, the contribution of ILC3s to inflammatory bowel disease (IBD) remains poorly understood. Throughout a lifetime, the function and fate of ILC3s appear to be strongly influenced by environmental cues, ranging from the maternal influences during gestation to host-derived signals throughout life. Understanding the mechanisms underlining imprinting processes is essential for further delineating mechanisms during chronic inflammation and disease establishment.

Here, we propose to address three key questions: How is trained immunity established in ILC3s? How can ILC3-mediated protective immunity be ensured? And how ILC3 responses could be modulated to offer new therapeutic opportunities in IBD?

Your role:

As a postdoctoral researcher, you will:

• Lead and develop a research project within the framework of this ANR project;
• Investigate cellular and molecular mechanisms underlying ILC3 inflammatory imprinting in health and IBD;
• Collaborate within a dynamic, international research team and contribute to supervising of junior members and students;
• Present results at national and international meetings;
• Draft manuscripts and contribute to future grant proposals.

Candidate:

We are seeking a highly motivated early-career scientist with:

• A PhD in Life Sciences (immunology or cell biology);
• Solid expertise in immunology or cell biology, with solid experimental lab skills;
• Experience with animal models (mouse work) and advanced immunological techniques;
• Skills in RNAseq analysis (highly valued);
• A strong commitment, team spirit, communication and organizational skills;
• Ability to work independently and contribute to collaborative projects;
• Excellent written and spoken English.