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Develop melt-spun liquid/gel-core fibers with polyolefin sheaths and functionalized, hydrophobic cores; Explore selective scavenger systems for transition metal (TM) ions and HF, including chelating ligands, reactive nanoparticles and additives; Optimize
Design and execute genome-wide CRISPR knockout, CRISPRa, and CRISPRi screens in mammalian cell models. Validate screening hits using arrayed CRISPR experiments and orthogonal functional assays in relevant disease models Establish, optimize, and routinely