Post-Doctoral Fellow in Targeted Proteomics

Post-Doctoral Fellow in Targeted Proteomics

LIH - Luxembourg Institute of Health

Strassen, Luxembourg

Background:

Cytokines are small signalling proteins essential for immune communication, acting through autocrine or paracrine mechanisms via specific receptors. Traditionally, cytokine quantification relies on antibody-based assays, which, despite widespread use, suffer from reproducibility issues due to antibody variability and the use of animal-derived reagents. These limitations result in high setup and maintenance costs. Advances in mass spectrometry now offer alternative solutions. Modern instruments can detect proteins at cytokine-level concentrations with exceptional sensitivity and specificity. Targeted proteomics enables the simultaneous quantification of large cytokine panels, offering high multiplexing at reduced variability and cost. In this project, we aim to develop a novel, antibody-free measurement platform capable of quantifying more than one hundred cytokines in biofluids. This method promises a cost-effective, robust, and scalable alternative to current cytokine assays, with broad applications in research and clinical diagnostics.

Objective: The post-doctoral fellow will work on the development of a robust detection pipeline for cytokines in plasma and other body fluids.

Key Accountabilities:

• PhD in biochemistry, Biomedical Sciences or Chemistry.
• Mass spectrometry-based proteomics.
• Data analysis of large proteomics datasets.
• Experience in cell culture and molecular biology.
• Languages skills: fluent command of English; knowledge of another language of the European Union is an asset.